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Pain knowledge bank: GI microbiome in opioid-induced bowel dysfunction

Recent data from animal studies demonstrated that long-term morphine treatment significantly alters gut microbial composition, explains Professor Benoit Coffin

The quest for biomarkers in pain medicine: a long way to go, but the journey has begun

If identified, suitable pain biomarkers may offer a measurement of the biological processes that underlie the pain experience. Dr Emmanuel Bäckryd and colleagues review the current state of play regarding the identification of biomarkers for pain conditions

Assessing opioid-induced constipation and bowel dysfunction

Bowel dysfunction and constipation are common side-effects of opioid therapy and a number of tools may be used to assess these symptoms, and inform treatment and management. However not all take into account the pathophysiology of opioid-induced constipation and bowel dysfunction, including the specific mechanisms of opioids on the gut, writes Professor Asbjørn M Drewes

Pain management in multiple myeloma

Multiple myeloma is one of the more common haematological cancers. Many patients experience pain from bone disease, indeed it is often the presenting symptom. Professor Heinz Ludwig discusses the aetiology of myeloma bone pain and the treatment options available

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