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Basic and preclinical science


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8 items

Pain knowledge bank: GI microbiome in opioid-induced bowel dysfunction

Recent data from animal studies demonstrated that long-term morphine treatment significantly alters gut microbial composition, explains Professor Benoit Coffin

Pharmacogenetics in pain treatment

Experimental models of pain have suggested that genetic variation can help explain differences in inter-individual response to analgesic drugs, write Dr Anne E Olesen and Professor Asbjørn M Drewes

CYP2D6 and the metabolism of codeine

Dr Wojciech Leppert describes how individual differences in codeine metabolism are related to the expression of CYP2D6 enzymes

Emerging acute and preventive treatments for migraine

Developments in the field of migraine management are ongoing, explains Professor Fabio Antonaci

Chronic pain and the role of opioids in pain management

The successful control and relief of chronic pain should be based on an understanding of the neurophysiological mechanisms and pathways involved and the role of opioids in pharmacological management is important, explains Dr Michael Überall

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